Curated research to understand technology benefits, comparisons, and limitations, prioritizing studies that identify devices or brands in our portfolio.
Procedure evidence2017 · Brouwer PA et al.
PLDD vs microdiscectomy: two-year evaluation
Percutaneous laser disc decompression versus conventional microdiscectomy for patients with sciatica: Two-year results of a randomised controlled trial
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
Multicentre randomised trial · Surgical candidates with contained disc herniation
Findings: A PLDD strategy with surgery when needed had non-inferior two-year outcomes compared with a microdiscectomy strategy. 48% of the PLDD group avoided surgery.
Points to consider: Reintervention was higher after PLDD: 52% versus 21%. Results apply to selected patients with herniation occupying less than one-third of the spinal canal.
Device & relevance: PLDD procedure research; a match to current biolitec device models has not been verified.
DOI: 10.1177/1591019917699981
General clinical evidence2020 · Garza JR et al.
SVF in knee osteoarthritis: placebo-controlled trial
Clinical Efficacy of Intra-articular Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Double-Blinded Prospective Randomized Controlled Clinical Trial
The American journal of sports medicine
Double-blind randomised trial · 39 patients · Two SVF doses vs placebo
Findings: WOMAC symptom scores improved more in the SVF groups than with placebo through 12 months.
Points to consider: Small sample; MRI showed no change in cartilage thickness. Read alongside the larger MILES trial, which used different methods and comparators.
Device & relevance: The processing method in this study has not been matched to SONICSTEM; it is not direct evidence for the Cellabsys device.
DOI: 10.1177/0363546519899923
General clinical evidence2023 · Mautner et al.
MILES: cell therapy vs corticosteroids for the knee
Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial
Nature Medicine
Multicentre randomised trial · 480 participants · Grade II–IV knee osteoarthritis
Findings: At one year, SVF, bone marrow aspirate concentrate, and umbilical cord tissue-derived cells were not superior to corticosteroids for the primary pain outcome.
Points to consider: No significant change in MRI osteoarthritis scores was found. These findings cannot be generalized to all cell preparations or processing methods.
Device & relevance: General cell therapy evidence; not a SONICSTEM clinical trial.
DOI: 10.1038/s41591-023-02632-w
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Reading evidence in context.
A model label means the study names a device matching the catalog. A brand label identifies the same brand, while the offered model still needs matching. Procedural and general clinical evidence provide context; findings do not automatically establish benefits for every device.
Summaries support education and discussion with healthcare professionals. Links open original publications; full-text availability depends on publisher access. Curated September 9, 2026.
