General clinical evidence2023 · Mautner et al.
MILES: cell therapy vs corticosteroids for the knee
Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial
Nature Medicine
Findings: At one year, SVF, bone marrow aspirate concentrate, and umbilical cord tissue-derived cells were not superior to corticosteroids for the primary pain outcome.
Points to consider: No significant change in MRI osteoarthritis scores was found. These findings cannot be generalized to all cell preparations or processing methods.
Device & relevance: General cell therapy evidence; not a SONICSTEM clinical trial.